Features of vascular-platelet hemostasis at different stages of physiological pregnancy

A prospective study of the vascular-platelet link of hemostasis was carried out in women aged 18 to 35 years at various stages of physiological pregnancy and on days 2–3 after spontaneous delivery.

The researchers set themselves the goal of establishing acceptable ranges for platelet aggregation, von Willebrand factor activity and levels, and ADAMTS-13 metalloproteinase during a physiological pregnancy.

The results obtained revealed an increasing activation of platelets (when studying their function using a “small” dose of ADP), an increase in the activity and amount of von Willebrand factor in combination with a depression in the activity of ADAMTS-13 metalloproteinase with increasing gestational age.

The data obtained clarify the mechanisms of platelet activation during pregnancy https://en.wikipedia.org/wiki/Pregnancy and can be a guideline for distinguishing between norm and pathology, differential diagnosis of blood clotting disorders and the formation of risk groups for bleeding and thrombosis during this period of a woman’s life.